Succinic Acid → HCID 21704894, compound

Participants

Reaction Steps

1-methyl-4-[(4-chloro-2-thienyl)-(4-fluorophenyl)]methylenepiperidine.succinate The above amine (64.6 g) was dissolved in methanol (640 ml, succinic acid (24.88 g) was added, the solution was taken to dryness and the residual solid (89.4 g was dissolved in hot ethanol (1.1 l). The solution was reduced in volume (200 ml), cooled in an ice/water bath and the resultant solid was filtered and washed with ethanol (200 ml). The solid was dried under vacuo at 50° C. to give 1-methyl-4-[(4-chloro-2-thienyl)-(4-fluorophenyl)]methylenepiperidine succinate (1;1 salt) (78.2 g) as an off-white solid; m.p. 171° C.

Provenance & Evidence