HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidinedione → 5-(4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Piperidinium acetate | HCID 3014295 | — |
| Reactant | 4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]-benzaldehyde | HCID 10038089 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-(4-[2-(N-Methyl-N-(2-pyrimidinyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione | HCID 54227469 | — |
Reaction Steps
A solution of 4-[2-(N-methyl-N-(2-pyrimidinyl)amino) ethoxy]benzaldehyde (1.7 g) and 2,4-thiazolidinedione (0.7 g) in toluene (10 ml) containing a catalytic quantity of piperidinium acetate was boiled under reflux in a Dean and Stark apparatus for 2 hours. The mixture was cooled and filtered to give the title compound (mp 189-90° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288095B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-09ee37f04a6d4cfa95a1158b23c24c18 |
| Source note | uspto-grants-2001_09 |