反应详情

Ethyl 5-(4-methylphenyl)-2-(1-naphthyl)imidazole-4-carboxylate (4.5 g) was dissolved in ethyl alcohol (90 ml) and 1 M sodium hydroxide solution (38 ml) was added. The reaction mixture was refluxed under heating for 12 hr, and the mixture was concentrated under reduced pressure. To the obtained residue were added water and ethyl acetate, and the mixture was partitioned. The aqueous layer was filtered, and aqueous citric acid was added to the filtrate. The precipitated crystals were collected by filtration to give 5-(4-methylphenyl)-2-(1-naphthyl)imidazole-4-carboxylic acid (3.3 g), melting point 165° C. (decomposition).

1. temperatureThe reaction mixture was refluxed
2. temperatureunder heating for 12 hr
3. concentrationthe mixture was concentrated under reduced pressure
4. additionTo the obtained residue were added water and ethyl acetate
5. customthe mixture was partitioned
6. filtrationThe aqueous layer was filtered
7. additionaqueous citric acid was added to the filtrate
8. filtrationThe precipitated crystals were collected by filtration