4-Chlorobenzylamine → HCID 178450797, compound

HRID 1595325Notes

Reaction equation

HRID 1595325 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[Cl:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[Cl:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]2[NH:25][C:11]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 660364-ChlorobenzylamineHCID 178451310HCID 178451310, compound

Product 1

HCID 178450797HCID 178450797, compoundYield 34.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(4-pyridyl)propionate (3.9 g) and 4-chlorobenzylamine (3.0 g) were dissolved in toluene (80 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 10 to give tert-butyl 2-(4-chlorophenyl)-5-(4-pyridyl)imidazole-4-carboxylate (1.9 g), melting point 206-207° C.

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-ed17ebbd80044403a8c2eacf53eeedf9
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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