4-Nitrobenzylamine → HCID 178450801, compound

HRID 1595327Notes

Reaction equation

HRID 1595327 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1)([O-:21])=[O:20]>C1(C)C=CC=CC=1>[N+:19]([C:22]1[CH:23]=[CH:24][C:25]([C:26]2[NH:27][C:11]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)=[CH:28][CH:29]=1)([O-:21])=[O:20]

Participants

4

Reactant 2

HCID 291474-NitrobenzylamineHCID 178451310HCID 178451310, compound

Product 1

HCID 178450801HCID 178450801, compoundYield 15.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(4-pyridyl)propionate (3.0 g) and 4-nitrobenzylamine (2.2 g) were dissolved in toluene (40 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 10 to give tert-butyl 2-(4-nitrophenyl)-5-(4-pyridyl)imidazole-4-carboxylate (0.7 g), melting point not less than 280° C.

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-a5afb033ac1e4aec8f7aa5366dc9e1b4
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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