反应详情

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate(12.8 g) and 2-aminomethylnaphthalene (10.3 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(2-naphthyl)imidazole-4-carboxylate (4.8 9g). 0.5 g therefrom was dissolved in ethyl alcohol (10 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(2-naphthyl)imidazole-4-carboxylic acid (0.26 g), melting point 227° C. (decomposition).

1. additiontreated in the same manner as