1-(2-Naphthyl)methanamine → HCID 178470171, 화합물

HRID 1595328노트

반응식

HRID 1595328 반응식
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:18][CH2:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=1>>[CH3:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[NH:18][C:19]([C:20]3[CH:29]=[CH:28][C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=3)=[N:2][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:12][CH:13]=1

참가 물질

3

반응물 2

HCID 1372821-(2-Naphthyl)methanamineHCID 178472891HCID 178472891, 화합물

생성물 1

HCID 178470171HCID 178470171, 화합물

실험 절차

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate(12.8 g) and 2-aminomethylnaphthalene (10.3 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methylphenyl)-2-(2-naphthyl)imidazole-4-carboxylate (4.8 9g). 0.5 g therefrom was dissolved in ethyl alcohol (10 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methylphenyl)-2-(2-naphthyl)imidazole-4-carboxylic acid (0.26 g), melting point 227° C. (decomposition).

후처리

  1. additiontreated in the same manner as

출처 및 근거

ORD 기록
ord-bb53cee2e4d745e08e6ced2c10d11caa
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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