反应详情

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (16.0 g) and 1-(aminomethyl)-4-methoxynaphthalene (15.3 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)-imidazole-4-carboxylate (22.2 g), which was dissolved in ethyl alcohol (450 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)imidazole-4-carboxylic acid (12.1 g), melting point 226° C. (decomposition).

1. additiontreated in the same manner as