4-Methoxynaphthalen-1-ylmethylamine → Ethyl 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)-imidazole-4-carboxylate

HRID 1595329노트

반응식

HRID 1595329 반응식
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:18][CH2:19][C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([O:30][CH3:31])=[CH:22][CH:21]=1>>[CH3:31][O:30][C:23]1[C:24]2[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:20]([C:19]2[NH:18][C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:2]=2)=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 591394-Methoxynaphthalen-1-ylmethylamineHCID 178472891HCID 178472891, 화합물

생성물 1

HCID 178470214Ethyl 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)-imidazole-4-carboxylate수율 84.5%

실험 절차

Ethyl 2-hydroxyimino-3-(4-methylphenyl)-3-oxopropionate (16.0 g) and 1-(aminomethyl)-4-methoxynaphthalene (15.3 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)-imidazole-4-carboxylate (22.2 g), which was dissolved in ethyl alcohol (450 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-methoxy-1-naphthyl)-5-(4-methylphenyl)imidazole-4-carboxylic acid (12.1 g), melting point 226° C. (decomposition).

후처리

  1. additiontreated in the same manner as

출처 및 근거

ORD 기록
ord-8c715b29413d4628a9332231345b9669
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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