反应详情

Ethyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate (10.0 g) and 1-aminomethylnaphthalene (7.0 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-chlorophenyl)-2-(1-naphthyl)imidazole-4-carboxylate (6.6 g). 6.0 g therefrom was dissolved in ethyl alcohol (120 ml), and 1 M sodium hydroxide solution (45 ml) was added. The reaction mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-chlorophenyl)-2-(1-naphthyl)-imidazole-4-carboxyic acid (4.1 g), melting point 210° C. (decomposition).

1. additiontreated in the same manner as