反应详情

Ethyl 2-hydroxyimino-3-phenyl-3-oxopropionate (10.0 g) and 1-aminomethylnaphthalene (7.8 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2-(1-naphthyl)-5-phenylimidazole-4-carboxylate (6.4 g). 6.0 g therefrom was dissolved in ethyl alcohol (120 ml) and 1 M sodium hydroxide solution (45 ml) was added. The mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(1-naphthyl)-5-phenylimidazole-4carboxyic acid (4.1 g), melting point 172° C. (decomposition).

1. additiontreated in the same manner as