4-Methylbenzylamine → HCID 178423978, compound

HRID 1595342Notes

Reaction equation

HRID 1595342 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[CH3:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24][NH2:25])=[CH:22][CH:21]=1>C(#N)C>[CH3:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]2[NH:25][C:11]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 660354-MethylbenzylamineHCID 178451310HCID 178451310, compound

Product 1

HCID 178423978HCID 178423978, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(4-pyridyl)propionate and 4-methylbenzylamine were dissolved in acetonitrile (80 ml). The mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 5 to give tert-butyl 2-(4-methylphenyl)-5-(4-pyridyl)imidazole-4-carboxylate.

Workup

  1. customThe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-303fd13a61c64d3482c83170aaf40d59
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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