反应详情

Ethyl 2-hydroxyimino-3-(4-methoxyphenyl)-3-oxopropionate (105.2 g) and 4-nitrobenzylamine (76.4 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (55.1 g), which was dissolved in ethyl alcohol. 1 M Sodium hydroxide solution was added and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylic acid (40.3 g), melting point 205-208° C. (decomposition).

1. additiontreated in the same manner as