4-Nitrobenzylamine → HCID 178470204, compound

Participants

Reaction Steps

Ethyl 2-hydroxyimino-3-oxo-3-(4-trifluoromethylphenyl)-propionate (24.6 g) and 4-nitrobenzylamine (14.0 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2-(4-nitrophenyl)-5-(4-trifluoromethylphenyl)-imidazole-4-carboxylate (10.6 g). 9.0 g therefrom was dissolved in ethyl alcohol. 1 M Sodium hydroxide solution was added and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-nitrophenyl)-5-(4-trifluoromethylphenyl)imidazole-4-carboxylic acid (8.2 g), melting point 172-174° C. (decomposition).

Provenance & Evidence