反应详情

Ethyl 2-hydroxyimino-3-phenyl-3-oxopropionate (36.1 g) and 4-nitrobenzylamine (27.9 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2-(4-nitrophenyl)-5-phenylimidazole-4-carboxylate (19.2 g). 18.0 g therefrom was dissolved in ethyl alcohol. 1 M Sodium hydroxide solution was added and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-nitrophenyl)-5-phenylimidazole-4-carboxylic acid (12.8 g), melting point 175-178° C. (decomposition).

1. additiontreated in the same manner as