4-Nitrobenzylamine → HCID 178470209, compound

HRID 1595346Notes

Reaction equation

HRID 1595346 reaction equation
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:20]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1)([O-:22])=[O:21]>>[N+:20]([C:23]1[CH:24]=[CH:25][C:26]([C:27]2[NH:28][C:9]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:2]=2)=[CH:29][CH:30]=1)([O-:22])=[O:21]

Participants

3

Reactant 2

HCID 291474-NitrobenzylamineHCID 178472899HCID 178472899, compound

Product 1

HCID 178470209HCID 178470209, compound

Procedure

Ethyl 2-hydroxyimino-3-(4-nitrophenyl)-3-oxopropionate and 4-nitrobenzylamine are reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 2,5-bis(4-nitrophenyl)imidazole-4-carboxylate, which is dissolved in ethyl alcohol. 1 M Sodium hydroxide solution is added and the mixture is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2,5-bis(4-nitrophenyl)imidazole-4-carboxylic acid.

Workup

  1. additiontreated in the same manner as

Sources & evidence

ORD record
ord-697543946be34142963b68e9bde7ea69
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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