Sodium Hydroxide → HCID 178466155, compound

HRID 1595352Notes

Reaction equation

HRID 1595352 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][C:13]([C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[N:12][C:11]=2[C:24]([O:26]CC)=[O:25])=[CH:6][CH:5]=1)[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][C:13]([C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=3)=[N:12][C:11]=2[C:24]([OH:26])=[O:25])=[CH:6][CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470211HCID 178470211, compound

Product 1

HCID 178466155HCID 178466155, compoundYield 120.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(4-ethoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (27.6 g) was dissolved in ethanol. 1 M Sodium hydroxide solution was added and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-ethoxyphenyl)-2-(4-nitrophenyl) imidazole-4-carboxylic acid (30.7 g), melting point 148-152° C.

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-4e41f80cac4844d3be867e1e77e56fa7
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

Loading…