(3-Methyl-4-nitrophenyl)methanamine → Ethyl 5-(4-methoxyphenyl)-2-(3-methyl-4-nitrophenyl)-imidazole-4-carboxylate

Beteiligte Stoffe

Reaktionsschritte

Ethyl 2-hydroxyimino-3-(4-methoxyphenyl)-3-oxopropionate (121.6 g) and 3-methyl-4-nitrobenzylamine (105.4 g) were reacted in the same manner as in Starting Material Synthetic Example 1. After the reaction, the solvent was evaporated under reduced pressure and the residue was subjected to silica gel column chromatography to give ethyl 5-(4-methoxyphenyl)-2-(3-methyl-4-nitrophenyl)imidazole-4-carboxylate (41.5 g), melting point 187-191° C.

Herkunft & Nachweise