Sodium Hydroxide → HCID 178489046, compound

HRID 1595354Notes

Reaction equation

HRID 1595354 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[C:16]([CH3:23])[CH:15]=3)=[N:11][C:10]=2[C:24]([O:26]CC)=[O:25])=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[C:16]([CH3:23])[CH:15]=3)=[N:11][C:10]=2[C:24]([OH:26])=[O:25])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470213Ethyl 5-(4-methoxyphenyl)-2-(3-methyl-4-nitrophenyl)-imidazole-4-carboxylate

Product 1

HCID 178489046HCID 178489046, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(4-methoxyphenyl)-2-(3-methyl-4-nitrophenyl)-imidazole-4-carboxylate (29 g) was dissolved in ethanol and 2 M sodium hydroxide solution was added. The mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methoxyphenyl)-2-(3-methyl-4-nitrophenyl)imidazole-4-carboxylic acid (20.9 g), melting point 229-230° C.

Workup

  1. customThe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-74df1cf16f54466b812ad24ad6207d4e
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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