4-Nitrobenzylamine → HCID 178470212, compound

HRID 1595356Notes

Reaction equation

O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]([CH3:20])[CH3:19])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:21]([C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1)([O-:23])=[O:22]>>[CH:18]([O:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[NH:29][C:28]([C:27]3[CH:26]=[CH:25][C:24]([N+:21]([O-:23])=[O:22])=[CH:31][CH:30]=3)=[N:2][C:3]=2[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:12][CH:13]=1)([CH3:20])[CH3:19]

Participants

Reactant 2

HCID 291474-Nitrobenzylamine

HCID 178472902HCID 178472902, compound

Product 1

HCID 178470212HCID 178470212, compoundYield 19.8%

Procedure

Ethyl 2-hydroxyimino-3-(4-isopropoxyphenyl)-3-oxopropionate (15.0 g) and 4-nitrobenzylamine (11.2 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-isopropoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (4.2 g).

Workup

additiontreated in the same manner as

Sources & evidence

ORD record: ord-0b5094e1af404510a9cf0db0bc50db5d
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288061B1

Reaction notes

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