4-tert-Butylbenzylamine → HCID 178470185, compound

HRID 1595358Notes

Reaction equation

HRID 1595358 reaction equation
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1)=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:20]([C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([C:24]1[CH:25]=[CH:26][C:27]([C:28]2[NH:29][C:9]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:2]=2)=[CH:30][CH:31]=1)([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 27356554-tert-ButylbenzylamineHCID 178472899HCID 178472899, compound

Product 1

HCID 178470185HCID 178470185, compoundYield 31.8%

Procedure

Ethyl 2-hydroxyimino-3-(4-nitrophenyl)-3-oxopropionate (47.8 g) and 4-tert-butylbenzylamine (35.4 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 10 to give ethyl 2-(4-tert-butylphenyl)-5-(4-nitrophenyl)imidazole-4-carboxylate (22.5 g), melting point 190-191° C.

Workup

  1. additiontreated in the same manner as

Sources & evidence

ORD record
ord-9d12a2497f4b4dd3961c0e4dac296d16
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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