Sodium Hydroxide → HCID 178440778, compound

HRID 1595359Notes

Reaction equation

HRID 1595359 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[NH:12][C:13]([C:21]3[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=3)=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[NH:12][C:13]([C:21]3[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=3)=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470185HCID 178470185, compound

Product 1

HCID 178440778HCID 178440778, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(4-tert-butylphenyl)-5-(4-nitrophenyl)imidazole-4-carboxylate (22.5 g), ethyl alcohol (1.2 L) and 1 M aqueous sodium hydroxide solution (225 ml) were reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-tert-butylphenyl)-5-(4-nitrophenyl)imidazole-4-carboxylic acid (18.4 g), melting point 223° C. (decomposition).

Workup

  1. additiontreated in the same manner as

Sources & evidence

ORD record
ord-41a6cdc112464c9480478dca5faa2e56
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

Loading…