Sodium Hydroxide → HCID 178489035, compound

HRID 1595361Notes

Reaction equation

HRID 1595361 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=3)=[N:11][C:10]=2[C:23]([O:25]CC)=[O:24])=[CH:5][CH:4]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=3)=[N:11][C:10]=2[C:23]([OH:25])=[O:24])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470188Ethyl 5-(4-methoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylate

Product 1

HCID 178489035HCID 178489035, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(4-methoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylate (13.3 g), ethyl alcohol (266 ml) and 1M aqueous sodium hydroxide solution (127 ml) were reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxyic acid (9.5 g), melting point 234-235° C.

Workup

  1. additiontreated in the same manner as

Sources & evidence

ORD record
ord-d20eb40b285f4c6db08fc8267c00b74e
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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