Sodium Hydroxide → HCID 178466154, compound

HRID 1595362Notes

Reaction equation

HRID 1595362 reaction equation
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[CH:13][CH:12]=1)=O)[C:4]([O:6]CC)=[O:5].[N+:20]([C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26][NH2:27])([O-:22])=[O:21].[OH-].[Na+]>C(O)C>[CH2:18]([O:17][C:14]1[CH:13]=[CH:12][C:11]([C:9]2[NH:27][C:26]([C:25]3[CH:28]=[CH:29][CH:30]=[C:23]([N+:20]([O-:22])=[O:21])[CH:24]=3)=[N:2][C:3]=2[C:4]([OH:6])=[O:5])=[CH:16][CH:15]=1)[CH3:19]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 1227223-NitrobenzylamineHCID 178472901HCID 178472901, compound

Product 1

HCID 178466154HCID 178466154, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(4-ethoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylate obtained by reacting and treating ethyl 2-hydroxyimino-3-(4-ethoxyphenyl)-3-oxopropionate and 3-nitrobenzylamine in the same manner as in Starting Material Synthetic Example 1 is dissolved in ethyl alcohol and 1 M aqueous sodium hydroxide solution is added. The mixture is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-ethoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylic acid.

Workup

  1. customThe mixture is reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-d1023bc0b50e4bb18ff935c5ffb42176
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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