Sodium Hydroxide → HCID 178489906, compound

HRID 1595363Notes

Reaction equation

HRID 1595363 reaction equation
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)=O)[C:4]([O:6]CC)=[O:5].[N+:19]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26])([O-:21])=[O:20].[OH-].[Na+]>C(O)C>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([C:9]2[NH:26][C:25]([C:24]3[CH:27]=[CH:28][CH:29]=[C:22]([N+:19]([O-:21])=[O:20])[CH:23]=3)=[N:2][C:3]=2[C:4]([OH:6])=[O:5])[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 1227223-NitrobenzylamineHCID 178472896HCID 178472896, compound

Product 1

HCID 178489906HCID 178489906, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(3-methoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylate obtained by reacting and treating ethyl 2-hydroxyimino-3-(3-methoxyphenyl)-3-oxopropionate and 3-nitrobenzylamine in the same manner as in Starting Material Synthetic Example 1 is dissolved in ethyl alcohol and 1 M aqueous sodium hydroxide solution is added. The mixture is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(3-methoxyphenyl)-2-(3-nitrophenyl)imidazole-4-carboxylic acid.

Workup

  1. customThe mixture is reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-5ae58065a6e641339ea365a618a2a899
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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