Sodium Hydroxide → HCID 178524858, compound

HRID 1595364Notes

Reaction equation

HRID 1595364 reaction equation
O[N:2]=[C:3]([C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)=O)[C:4]([O:6]CC)=[O:5].[N+:18]([C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25])([O-:20])=[O:19].[OH-].[Na+]>C(O)C>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:9]2[NH:25][C:24]([C:23]3[CH:26]=[CH:27][CH:28]=[C:21]([N+:18]([O-:20])=[O:19])[CH:22]=3)=[N:2][C:3]=2[C:4]([OH:6])=[O:5])=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 1227223-NitrobenzylamineHCID 178472894HCID 178472894, compound

Product 1

HCID 178524858HCID 178524858, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(4-chlorophenyl)-2-(3-nitrophenyl)imidazole-4-carboxylate obtained by reacting and treating ethyl 2-hydroxyimino-3-(4-chlorophenyl)-3-oxopropionate and 3-nitrobenzylamine in the same manner as in Starting Material Synthetic Example 1 is dissolved in ethyl alcohol and 1 M aqueous sodium hydroxide solution is added. The mixture is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-chlorophenyl)-2-(3-nitrophenyl)imidazole-4-carboxylic acid.

Workup

  1. customThe mixture is reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-ebf9be33989b4777888dfa551e44c5a8
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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