反应详情

Ethyl 5-(4-chlorophenyl)-2-(4-morpholinophenyl)imidazole-4-carboxylate (53.7 g) was dissolved in ethanol (540 ml) and 3N aqueous sodium hydroxide solution (217 ml), and the mixture was refluxed under heating for 5 hr and concentrated under reduced pressure. Water (100 ml) was added and the mixture was washed with toluene. The aqueous layer was neutralized with 10% aqueous citric acid solution and the precipitated crystals were collected by filtration to give the objective 5-(4-chlorophenyl)-2-(4-morpholinophenyl)imidazole-4-carboxyic acid (49.4 g), melting point 205° C. (decomposition).

1. temperatureunder heating for 5 hr
2. concentrationconcentrated under reduced pressure
3. additionWater (100 ml) was added
4. washthe mixture was washed with toluene
5. filtrationthe precipitated crystals were collected by filtration