HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(4-Methyl-1,4-diazepan-1-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 1-Methylhomopiperazine | HCID 228349 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(4-Methyl-1,4-diazepan-1-yl)benzonitrile | HCID 18001106 | — |
Reaction Steps
4-Fluorobenzonitrile (25.5 g), 4-methylhomopiperazine (26.2 ml) and potassium carbonate (28 g) were heated in DMSO for 15 hr. After heating, the reaction mixture was poured into water (1 L). The precipitated crystals were collected by filtration to give the objective 4-(4-methylhomopiperazin-1-yl)benzonitrile (34.6 g), melting point 82-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288061B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-fb26642aaa0e416385e74b155e3d5760 |
| Source note | uspto-grants-2001_09 |