Thionyl Chloride → N-((4-(chloromethyl)phenyl)methyl)acetamide

Participants

Reaction Steps

To a solution of N-(4-hydroxymethylphenylmethyl)acetamide (1.5 g) in chloroform (50 ml) was added thionyl chloride (0.73 ml) and the mixture was refluxed under heating for 1 hr. The solvent was evaporated and the obtained residue was crystallized from ethyl acetate to give the objective N-(4-chloromethylphenylmethyl)acetamide (1.8 g) as pale-yellow crystals, melting point 116-118° C.

Provenance & Evidence