[4-(Aminomethyl)phenyl]methanol → HCID 178450798, compound

HRID 1595380Notes

Reaction equation

HRID 1595380 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18](=O)[C:19](=[N:27]O)[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[CH:14][CH:13]=1>N1C=CC=CC=1>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[NH:10][C:9]([C:6]3[CH:7]=[CH:8][C:3]([CH2:2][OH:1])=[CH:4][CH:5]=3)=[N:27][C:19]=2[C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6496943[4-(Aminomethyl)phenyl]methanolHCID 178451307HCID 178451307, compound

Product 1

HCID 178450798HCID 178450798, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-(Hydroxymethyl)phenylmethylamine and tert-butyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate are dissolved in pyridine, and the mixture is treated in the same manner as in Starting Material Synthetic Example 170 to give the objective tert-butyl 5-(4-chlorophenyl)-2-(4-hydroxymethylphenyl)imidazole-4-carboxylate.

Workup

  1. additionthe mixture is treated in the same manner as

Sources & evidence

ORD record
ord-c10877665546470898d9ab45806218dc
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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