2-[4-(Aminomethyl)phenyl]ethan-1-ol → HCID 178450796, compound

HRID 1595383Notes

Reaction equation

HRID 1595383 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH2:11])=[CH:6][CH:5]=1.[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=O)[C:20](=[N:28]O)[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:15][CH:14]=1>N1C=CC=CC=1>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[NH:11][C:10]([C:7]3[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][OH:1])=[CH:5][CH:6]=3)=[N:28][C:20]=2[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 226014582-[4-(Aminomethyl)phenyl]ethan-1-olHCID 178451307HCID 178451307, compound

Product 1

HCID 178450796HCID 178450796, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-(2-Hydroxyethyl)phenylmethylamine and tert-butyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate are dissolved in pyridine, and the mixture is treated in the same manner as in Starting Material Synthetic Example 170 to give the objective tert-butyl 5-(4-chlorophenyl)-2-[4-(2-hydroxyethyl)phenyl]imidazole-4-carboxylate.

Workup

  1. additionthe mixture is treated in the same manner as

Sources & evidence

ORD record
ord-150718e5f4624901a1aa41b2b7ec665e
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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