2-Amino-4-phenylthiazole → HCID 178424016, compound

HRID 1595391Notes

Reaction equation

HRID 1595391 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10][C:9]=2[C:19](O)=[O:20])=[CH:4][CH:3]=1.[NH2:22][C:23]1[S:24][CH:25]=[C:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:27]=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[NH:12][C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:10][C:9]=2[C:19]([NH:22][C:23]2[S:24][CH:25]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:27]=2)=[O:20])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 403022-Amino-4-phenylthiazoleHCID 178424017HCID 178424017, compound

Product 1

HCID 178424016HCID 178424016, compoundYield 7.7%

Procedure

5-(4-Methylphenyl)-2-phenylimidazole-4-carboxylic acid (0.5 g) and 2-amino-4-phenylthiazole (0.55 g) were reacted and treated in the same manner as in Example 1 to give 5-(4-methylphenyl)-2-phenyl-N-(4-phenylthiazol-2-yl)imidazole-4-carboxamide (0.06 g), melting point 274-276° C.

Workup

  1. additiontreated in the same manner as in Example 1

Sources & evidence

ORD record
ord-36b7e111d33047348b70ccdc4419dbbc
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

Loading…