Stannous Chloride → HCID 178489037, compound

HRID 1595392Notes

Reaction equation

HRID 1595392 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1.[Sn](Cl)Cl>>[NH2:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2[NH:13][C:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)=[C:10]([C:23]([NH:25][C:26]3[S:27][CH:28]=[CH:29][N:30]=3)=[O:24])[N:11]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 178489042HCID 178489042, compound

Product 1

HCID 178489037HCID 178489037, compoundYield 35.2%

Procedure

5-(4-Methoxyphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.52 g) obtained in Example 47 and tin(II) chloride 6 hydrate (1.2 g) were reacted and treated in the same manner as in Example 59 to give 2-(4-aminophenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.17 g), melting point 257-258° C. (decomposition).

Workup

  1. additiontreated in the same manner as in Example 59

Sources & evidence

ORD record
ord-6ead14d78048433daf7fe84709ab67cd
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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