Stannous Chloride → HCID 178507446, compound

HRID 1595394Notes

Reaction equation

HRID 1595394 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:11][C:12]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[C:13]([C:15]([NH:17][C:18]3[S:19][CH:20]=[CH:21][N:22]=3)=[O:16])[N:14]=2)=[CH:6][CH:5]=1)([O-])=O.[Sn](Cl)Cl>>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:11][C:12]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[C:13]([C:15]([NH:17][C:18]3[S:19][CH:20]=[CH:21][N:22]=3)=[O:16])[N:14]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 24479Stannous ChlorideHCID 178522569HCID 178522569, compound

Product 1

HCID 178507446HCID 178507446, compoundYield 35.4%

Procedure

2-(4-Nitrophenyl)-5-phenyl-N-(2-thiazolyl)imidazole-4-carboxamide (0.52 g) obtained in Example 51 and tin(II) chloride 6 hydrate (1.2 g) were reacted and treated in the same manner as in Example 59 to give 2-(4-aminophenyl)-5-phenyl-N-(2-thiazolyl)imidazole-4-carboxamide (0.17 g), melting point 257-258° C. (decomposition).

Workup

  1. additiontreated in the same manner as in Example 59

Sources & evidence

ORD record
ord-7525e1e7668f48e0aef85722fa7971e7
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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