Sodium Hydroxide → HCID 178522566, compound

Participants

Reaction Steps

5-(4-Acetoxymethylphenyl)-2-(1-naphthyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (2.98 g) obtained in Example 60(2) was dissolved in acetone (250 ml) and 0.25 M aqueous sodium hydroxide solution (56 ml) was added under ice-cooling. The mixture was stirred at room temperature for 2 hr. Acetone was evaporated under reduced pressure and the residue was acidified with aqueous citric acid solution and extracted with ethyl acetate. The ethyl acetate layer was washed with water and the solvent was evaporated. The obtained residue was recrystallized from ethyl acetate to give 5-(4-hydroxymethylphenyl)-2-(1-naphthyl)-N-(2-thiazolyl)imidazole-4-carboxamide (2.08 g), melting point 226-228° C.

Provenance & Evidence