Pyridine → HCID 178474103, compound

Participants

Reaction Steps

2-(4-Aminophenyl)-5-(4-methylphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.30 g) obtained in Example 21 was dissolved in pyridine (20 ml) and acetyl chloride (0.8 ml) was added dropwise under ice-cooling. The mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated to give white crystals, which were recrystallized from ethyl acetate to give 2-(4-acetamidophenyl)-5-(methylphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.17 g), melting point 269-271° C.

Provenance & Evidence