Acetoxyacetyl chloride → HCID 178476484, compound

Participants

Reaction Steps

2-(4-Aminophenyl)-5-(4-methylphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.30 g) obtained in Example 21 was dissolved in pyridine (20 ml) and acetoxyacetyl chloride (0.1 ml) was added dropwise under ice-cooling. The mixture was stirred at room temperature for 4 hr. The reaction mixture was concentrated and the residue was purified by silica gel chromatography using, as a mobile phase, chloroform/ethyl acetate=20:1. Theresidue was recrystallized from ethyl acetate to give 4-[5-(4-methylphenyl)-4-(2-thiazolylcarbamoyl)imidazol-2-yl]phenylcarbamoylmethyl acetate (0.13 g), melting point 250° C. or above.

Provenance & Evidence