HCID 178522566, compound → HCID 178460432, compound

Participants

Reaction Steps

5-(4-Hydroxymethylphenyl)-2-(1-naphthyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (300 mg) obtained in Example 61 was dissolved in pyridine (5 ml) and propionic anhydride (5 ml), and the mixture was left standingfor 12 hr. Thereaction mixture was poured into icewater and extracted with ethyl acetate. The ethyl acetate layer was washed with water and, after drying, concentrated. The obtained residue was recrystallized from ethyl acetate to give 2-(1-naphthyl)-5-(4-propionyloxymethylphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (150 mg), melting point 281-283° C.

Provenance & Evidence