Dimethylamine → HCID 178483170, compound

HRID 1595416Notes

Reaction equation

HRID 1595416 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1.[CH3:31][NH:32][CH3:33]>>[ClH:1].[ClH:1].[CH3:31][N:32]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1)[CH3:33]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 178522570HCID 178522570, compound

Product 1

HCID 178483170HCID 178483170, compound

Procedure

5-(4-Chloromethylphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (900 mg) obtained in Example 94 and 50% aqueous dimethylamine solution (5 ml) were reacted and treated in the same manner as in Example 95 to give 5-(4-dimethylaminomethylphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)imidazole-4-carboxamide dihydrochloride (645 mg), melting point 273-279° C. (decomposition).

Workup

  1. additiontreated in the same manner as in Example 95

Sources & evidence

ORD record
ord-2e3a44123e3c4475900ff498986c7285
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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