Methanol → HCID 178489030, compound

Participants

Reaction Steps

5-(4-Methoxyphenyl)-2-(3-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide hydrochloride monohydrate (1.0 g) was suspended in a mixed solvent of methanol (100 ml) and dioxane (100 ml), and 10% palladium carbon (containing water 50%, 0.5 g) was added to carryoutcatalyticreductionatnormalpressure. Thereactionmixture was filtered and concentrated. The obtained crude crystals were recrystallized from methanol to give 2-(3-aminophenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide hydrochloride 3/2 hydrate (110 mg), melting point 245° C. (decomposition).

Provenance & Evidence