1,3,4-Thiadiazol-2-amine → HCID 178489043, compound

HRID 1595419Notes

Reaction equation

HRID 1595419 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([OH:25])=O)=[CH:5][CH:4]=1.S(Cl)(Cl)=O.[NH2:30][C:31]1[S:32][CH:33]=[N:34][N:35]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:11][C:10]=2[C:23]([NH:30][C:31]2[S:32][CH:33]=[N:34][N:35]=2)=[O:25])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 199091,3,4-Thiadiazol-2-amineHCID 24386Thionyl ChlorideHCID 178489044HCID 178489044, compound

Product 1

HCID 178489043HCID 178489043, compound

Procedure

5-(4-Methoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylic acid, 1 M hydrochloric acid—ether solution, thionyl chloride and 2-amino-1,3,4-thiadiazole are reacted and treated in the same manner as in Example 1 to give 5-(4-methoxyphenyl)-2-(4-nitrophenyl)-N-(1,3,4-thiadiazol-2-yl)imidazole-4-carboxamide.

Workup

  1. additiontreated in the same manner as in Example 1

Sources & evidence

ORD record
ord-c805857e99714e77985b7f75e496a8cc
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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