4,5-Dihydro-2-thiazolamine → HCID 178489041, compound

HRID 1595420Notes

Reaction equation

HRID 1595420 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:11][C:12]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)=[C:13]([C:15]([OH:17])=O)[N:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].S(Cl)(Cl)=O.[NH2:30][C:31]1[S:32][CH2:33][CH2:34][N:35]=1>>[CH3:25][O:24][C:21]1[CH:20]=[CH:19][C:18]([C:12]2[NH:11][C:10]([C:7]3[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=3)=[N:14][C:13]=2[C:15]([NH:30][C:31]2[S:32][CH2:33][CH2:34][N:35]=2)=[O:17])=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 156894,5-Dihydro-2-thiazolamineHCID 24386Thionyl ChlorideHCID 178489044HCID 178489044, compound

Product 1

HCID 178489041HCID 178489041, compound

Procedure

2-(4-Nitrophenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylic acid, 1 M hydrochloric acid—ether solution, thionyl chloride and 2-aminothiazoline were reacted and treated in the same manner as in Example 1 to give 5-(4-methoxyphenyl)-2-(4-nitrophenyl)-N-(2-thiazolinyl)imidazole-4-carboxamide.

Workup

  1. additiontreated in the same manner as in Example 1

Sources & evidence

ORD record
ord-59e8981a7f0e47069450e02423216a46
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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