Benzaldehyde, 4-(phenylmethoxy)- → Ethyl 2-(4-benzyloxyphenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylate

Participants

Reaction Steps

Ethyl 2-hydroxyimino-3-(4-methoxyphenyl)-3-oxopropionate, 4-benzyloxybenzaldehyde and ammonium acetate are reacted and treated in the same manner as in Example 22 to give ethyl 2-(4-benzyloxyphenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylate. Ethyl 2-(4-benzyloxyphenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylate is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 2-(4-benzyloxyphenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylic acid. 2-(4-Benzyloxyphenyl)-5-(4-methoxyphenyl)imidazole-4-carboxylic acid is reacted and treated in the same manner as in Example 1 to give 2-(4-benzyloxyphenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide.

Provenance & Evidence