反应详情

Ethyl 2-hydroxyimino-3-(4-methoxyphenyl)-3-oxopropionate, 4-(1-pyrrolidinyl)benzylamine is reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give ethyl 5-(4-methoxyphenyl)-2-(4-(1-pyrrolidinyl)phenyl)imidazole-4-carboxylate. Ethyl 5-(4-methoxyphenyl)-2-(4-(1-pyrrolidinyl)-phenyl)imidazole-4-carboxylate is reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(4-methoxyphenyl)-2-(4-(1-pyrrolidinyl)phenyl)imidazole-4-carboxylic acid. 5-(4-Methoxyphenyl)-2-(4-(1-pyrrolidinyl)phenyl)imidazole-4-carboxylicacid isreactedandtreatedinthesamemanneras in Example 1 to give 5-(4-methoxyphenyl)-2-(4-(1-pyrrolidinyl)phenyl)-N-(2-thiazolyl)imidazole-4-carboxamide.

1. additiontreated in the same manner as