Aluminium lithium hydride → HCID 178509635, compound

HRID 1595446Notes

Reaction equation

HRID 1595446 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]#[N:20])=[CH:15][CH:14]=3)=[N:10][C:9]=2[C:21]([NH:23][C:24]2[S:25][CH:26]=[CH:27][N:28]=2)=[O:22])=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:20][CH2:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[NH:12][C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)=[C:9]([C:21]([NH:23][C:24]3[S:25][CH:26]=[CH:27][N:28]=3)=[O:22])[N:10]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 178509634HCID 178509634, compound

Product 1

HCID 178509635HCID 178509635, compound

Procedure

5-(4-Chlorophenyl)-2-(4-cyanophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide obtained in Example 193 is reduced with LiAlH4 to give 2-(4-aminomethylphenyl)-5-(4-chlorophenyl)-N-(2-thiazolyl)imidazole-4-carboxamide.

Sources & evidence

ORD record
ord-e0d3c4ce0a304cb48e4257ab160a3daa
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

Loading…