Sodium Hydroxide → HCID 178522568, compound

HRID 1595447Notes

Reaction equation

HRID 1595447 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:13][C:14]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)=[C:15]([C:17]([NH:19][C:20]3[S:21][CH:22]=[CH:23][N:24]=3)=[O:18])[N:16]=2)=[CH:8][CH:7]=1)(=O)C.[OH-].[Na+]>>[Cl:31][C:28]1[CH:27]=[CH:26][C:25]([C:14]2[NH:13][C:12]([C:9]3[CH:8]=[CH:7][C:6]([CH2:5][OH:4])=[CH:11][CH:10]=3)=[N:16][C:15]=2[C:17]([NH:19][C:20]2[S:21][CH:22]=[CH:23][N:24]=2)=[O:18])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178475831HCID 178475831, compound

Product 1

HCID 178522568HCID 178522568, compound

Procedure

2-(4-Acetoxymethylphenyl)-5-(4-chlorophenyl)-N-(2-thiazolyl)imidazole-4-carboxamide obtained in Example 222 is hydrolyzed with aqueous sodium hydroxide solution to give the objective 5-(4-chlorophenyl)-2-(4-hydroxymethylphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide.

Sources & evidence

ORD record
ord-097fcf6bce194b2fa0bff2a02970532f
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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