Hydrochloric Acid → HCID 21705086, compound

Participants

Reaction Steps

Methyl N-(3-chlorophenylsulphonyl)indole-2-carboxylate (0.56 g) and lithium iodide (2.0 g) were dissolved in pyridine and heated at reflux for 6 hours, cooled to room temperature and poured into 2M HCl and extracted with diethyl ether. Combined organic extracts were dried (MgSO4) and concentrated in vacuo to give an oil which was purified by column chromatography using DCM-2% methanol as eluent to give the desired product as a white solid (0.24 g, 45%), mp 216-217°; NMR δ (CD3SOCD3) 7.30-8.10 (m, 9H); M/z(−) 334 (M−H+), 290, 226, 191, 180, 116.

Provenance & Evidence