Hydrochloric Acid → HCID 21705094, compound

Participants

Reaction Steps

Aqueous sodium hydrogencarbonate solution (16 ml, 50%) was added to methyl 4-acetoxy-N-(3,4-dichlorophenylsulphonyl)indole-2-carboxylate (0.63 g) in methanol (15 ml) and the reaction stirred for 48 hours at room temperature. The solution was then poured into 2M HCl and extracted with ethyl acetate. Combined organic extracts were dried (MgSO4) and concentrated in vacuo to give the desired product as a gum (0.5 g, 87%); NMR δ (CD3SOCD3) 3.83 (s, 3H), 6.71 (d, 1H), 7.31 (t, 1H), 7.42-7.5 (m, 2H), 7.92 (s, 1H), 10.31 (s, 1H); M/z (+) 402 (MH+), 400.

Provenance & Evidence