Ethanol → 8-Chloro-5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acid ethyl ester

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Reaction Steps

The product of Example 20 was converted to its ethyl ester by treatment with sulfuric acid in ethanol to give the title compound as an off-white solid: mp 202-204° C.; 1H NMR (DMSO-d6,): δ 1.39 (t, 3H), 4.00 (s, 2H), 4.38 (q, 2H), 7.11 (d, 1H), 7.48 (d, 1H), 7.52 (t, 1H), 7.67 (s, 1H), 7.79-7.84 (m, 2H), 11.86 (s, 1H); MS [EI, m/z]: 311 [M]+.

Provenance & Evidence