Thiazolidinedione → HCID 54436213, compound

Participants

Reaction Conditions

Reaction Steps

0.887 g (2.14 mmole) 4-[2-(4-formylphenoxy)ethyl]-3-(methylsulfonyloxy)phenyl methanesulfonate was dissolved in 8 ml dichloromethane. 0.314 g (2.68 mmole) 2,4-thiazolidinedione and 0.439 g (5.35 mmole) sodium acetate were added and everything was mixed together. The solvent was evaporated in vacuo and the mixture was heated under vacuum to 175° C. and kept at this temperature for 20 minutes (the mixture melted at ca. 100° C.). After cooling the reaction mixture was stirred in water and acetone. Acetic acid was added and the precipitate was collected by filtration, washed with acetone/water, pure water and dried to give 0.76 g (yield 69%) of 5-(4-[2-(2,4-dimethanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

Provenance & Evidence