4-Hydroxybenzaldehyde → HCID 21705012, compound

Participants

Reaction Steps

A mixture of 8.5 g (17.8 mmole) 4-(4-methoxyphenylsulfonyloxy)phenethyl 4-methoxy-1-benzenesulfonate, 2.16 g (17.7 mmole) 4-hydroxybenzaldehyde and 10 g (72.5 mmole) potassium carbonate in 60 g acetonitrile was refluxed over night. The salt was filtered off and the solvent was evaporated. The crude product was purified on silica gel using dichloromethane as eluent to give 7.4 g of 4-[2-(4-formylphenoxy)ethyl]phenyl 4-methoxy-1-benzenesulfonate (slightly polluted with the corresponding styrene product).

Provenance & Evidence