Ethyl Acetate → HCID 21705014, compound

Participants

Reaction Steps

1.2 g (2.35 mmole) 5-(4-[2-(4-(4-methoxyphenylsulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione was mixed with 200 ml warm ethyl acetate, 2 ml acetic acid and 1.2 g Pd/C (5%, 50% water) and hydrogenated for 4 hours at room temperature. 1.2 g more of the catalyst was added after 2 hours. The catalyst was filtered off and the solvent was evaporated in vacuo. The crude product was purified by chromatography on silica gel using dichloromethane/diisopropyl ether (gradient) as eluent to give 0.5 g of the desired product.

Provenance & Evidence